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Basem Al-Shayeb

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Basem Al-Shayeb is an Egyptian American microbiologist who is a co-founder (with Jacob Barrajo) and the former chief technology officer of Amber Bio[1], a biotechnology startup company in the San Francisco Bay Area which is trying to develop multi-kilobase RNA editing therapies using CRISPR-Cas systems.[2][3][4]

He received his PhD in microbial biology[5][6] as a National Science Foundation Fellow at the University of California, Berkeley and Innovative Genomics Institute,[7] where he conducted his dissertation work in the lab of Jennifer Doudna, and in the Earth and Planetary Science Department supervised by Jillian Banfield.[8]

During his time at UC Berkeley, he contributed as first or co-first author on publications describing the discovery of the largest known bacteriophages in Nature,[9][10][11] the smallest (at the time) CRISPR-Cas genome editing systems in Science and Cell [12][10][13][14] and a new form of extrachromosomal DNA elements, termed "Borgs," found in methane-oxidizing archaea (Methanoperedens spp.) in Nature.[15][16][17] Subsequently, he contributed to work led by his co-founder and CEO, Jacob Barrajo, reporting a strategy for programmable editing of multi-kilobase RNAs.[18] He was listed in Forbes 30 Under 30 and Arab America's 30 Under 30 in 2021, [11][19][20] and Forbes All-Star Alumni in 2024 for his scientific contributions.[21]

References

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  1. ^ Rice, India. "This Startup Just Raised $26 Million To Develop Safer Gene Editing Tools". Forbes. Retrieved 2024-06-27.
  2. ^ "New RNA-Editing Company, Amber Bio, Launches Multi-Kilobase Editing Platform". GEN - Genetic Engineering and Biotechnology News. 2023-08-03. Retrieved 2024-06-27.
  3. ^ https://www.businesswire.com/news/home/20230803489484/en/Amber-Bio-Raises-26-Million-Seed-Financing-Co-Led-by-Playground-Global-and-Andreessen-Horowitz-to-Advance-New-RNA-Based-Gene-Editing-Platform
  4. ^ "RNA editing start-up Amber Bio launches with $26 million". Chemical & Engineering News. Retrieved 2024-06-27.
  5. ^ "ORCID". orcid.org. Retrieved 2024-08-17.
  6. ^ "Basem Al-Shayeb". Plant & Microbial Biology | University of California, Berkeley. Retrieved 2024-08-18.
  7. ^ "Meet an IGI Scientist: Basem Al-Shayeb". Innovative Genomics Institute (IGI). Retrieved 2022-03-13.
  8. ^ "Basem Al-Shayeb | Earth & Planetary Science". eps.berkeley.edu. Retrieved 2024-08-18.
  9. ^ York, Ashley (April 2020). "Too big to be ignored". Nature Reviews Microbiology. 18 (4): 192. doi:10.1038/s41579-020-0341-z. ISSN 1740-1534. PMID 32066943.
  10. ^ a b Pausch, Patrick; Al-Shayeb, Basem; Bisom-Rapp, Ezra; Tsuchida, Connor A.; Li, Zheng; Cress, Brady F.; Knott, Gavin J.; Jacobsen, Steven E.; Banfield, Jillian F.; Doudna, Jennifer A. (2020-07-17). "CRISPR-CasΦ from huge phages is a hypercompact genome editor". Science. 369 (6501): 333–337. Bibcode:2020Sci...369..333P. doi:10.1126/science.abb1400. ISSN 0036-8075. PMC 8207990. PMID 32675376.
  11. ^ a b Knapp, Alex. "30 Under 30 In Science 2021: Building Better Trees, Supernova Simulations And Holograms". Forbes. Retrieved 2024-08-17.
  12. ^ "News: Tiny but Mighty: How Researchers Found a New Game-Changing CRISPR Tool". CRISPR Medicine. Retrieved 2024-08-15.
  13. ^ "New Compact Genome Editors Found in Viruses". Innovative Genomics Institute (IGI). Retrieved 2024-08-17.
  14. ^ Al-Shayeb, Basem; Skopintsev, Petr; Soczek, Katarzyna M.; Stahl, Elizabeth C.; Li, Zheng; Groover, Evan; Smock, Dylan; Eggers, Amy R.; Pausch, Patrick; Cress, Brady F.; Huang, Carolyn J.; Staskawicz, Brian; Savage, David F.; Jacobsen, Steven E.; Banfield, Jillian F. (2022-11-23). "Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors". Cell. 185 (24): 4574–4586.e16. doi:10.1016/j.cell.2022.10.020. ISSN 0092-8674. PMID 36423580.
  15. ^ "Scientists discover Borgs, DNA strands that assimilate genes from their hosts". Chemical & Engineering News. Retrieved 2024-08-17.
  16. ^ Al-Shayeb, Basem; Schoelmerich, Marie C.; West-Roberts, Jacob; Valentin-Alvarado, Luis E.; Sachdeva, Rohan; Mullen, Susan; Crits-Christoph, Alexander; Wilkins, Michael J.; Williams, Kenneth H.; Doudna, Jennifer A.; Banfield, Jillian F. (October 2022). "Borgs are giant genetic elements with potential to expand metabolic capacity". Nature. 610 (7933): 731–736. Bibcode:2022Natur.610..731A. doi:10.1038/s41586-022-05256-1. ISSN 1476-4687. PMC 9605863. PMID 36261517.
  17. ^ "Previously undiscovered DNA 'borgs' found on California wetlands". The Independent. 2021-07-30.
  18. ^ Borrajo, Jacob; Javanmardi, Kamyab; Griffin, James; St. Martin, Susan J.; Yao, David; Hill, Kaisle; Blainey, Paul C.; Al-Shayeb, Basem (2023-08-18). "Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicing". bioRxiv: 2023.08.18.553620. doi:10.1101/2023.08.18.553620. PMID 37645763.
  19. ^ "Basem Al-Shayeb". Forbes. Retrieved 2022-03-13.
  20. ^ "Arab America Foundation Announces 30 Under 30 Awardees-Class of 2021". Arab America. 2021-10-06. Retrieved 2022-10-04.
  21. ^ "Forbes 30 Under 30 2024: Science". Forbes. Retrieved 2024-08-17.
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